Penicillin concentrations after increased doses of benzathine penicillin G for prevention of secondary rheumatic fever
نویسندگان
چکیده
منابع مشابه
SERUM PENICILLIN LEVEL A FTER INTRAMUSCULA R INJECTION OF 1,200,000 UNITS OF BENZATHINE PENICILLIN G IN CHILDREN WITH RHEUMATIC FEVER
The most accepted method of secondary prophylaxis in rheumatic fever (RF) has been an injection of 1,200,000 units of benzathine penicillin G (BPG) every 4 weeks, but recurrences have been reported in some patients despite such a prophylaxis program. The WHO recommended BPG injections every 3 weeks in high risk patients and situations due to some published data in favor of inadequacy of on...
متن کاملserum penicillin level a fter intramuscula r injection of 1,200,000 units of benzathine penicillin g in children with rheumatic fever
the most accepted method of secondary prophylaxis in rheumatic fever (rf) has been an injection of 1,200,000 units of benzathine penicillin g (bpg) every 4 weeks, but recurrences have been reported in some patients despite such a prophylaxis program. the who recommended bpg injections every 3 weeks in high risk patients and situations due to some published data in favor of inadequacy of once ev...
متن کاملConfirmed penicillin allergy among patients receiving benzathine penicillin prophylaxis for acute rheumatic fever.
BACKGROUND Beta-lactam antibiotics are the most frequent drugs prescribed in children worldwide. Acute rheumatic fever (ARF) is the major cause of acquired heart disease among children and adolescents. Recurrences due to inadequate penicillin prophylaxis are responsible for chronic valvular lesions requiring surgery. The fear of a severe allergic reaction is the leading cause of discontinuing p...
متن کاملNicolau Syndrome after Intramuscular Benzathine Penicillin Injection
A 3-year-old boy was admitted to the emergency department with right lower limb pain, edema, and livedoid discoloration that occurred immediately after intramuscular injection of benzathine penicillin. The patient was diagnosed with Nicolau syndrome, a rare complication of intramuscular injection presumed to be related to the inadvertent intravascular injection. It was first reported following ...
متن کاملFactors associated with loss of penicillin G concentrations in serum after intramuscular benzathine penicillin G injection: a meta-analysis.
BACKGROUND An interval of 3-4 weeks between intramuscular injections of 1.2 million units of benzathine penicillin G as prophylaxis against group A streptococcal infection is recommended by health organizations for patients with pediatric rheumatic fever and heart disease. METHODS We reviewed the literature for evidence of the persistence of serum penicillin G during the first 4 weeks after t...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 1994
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.38.5.1203